Non-small cell lung cancer (NSCLC) is the most common form of lung cancer which remains the deadliest malignancy worldwide(Siegel et al.,2019).In general,NSCLC can be divided into several subtypes,including adenocarcinoma (ADC),squamous cell carci-noma (SCC),adeno-squamous cell carcinoma (AD-SCC) and large cell carcinoma (LCC).With the development of gene detection tech-nology,driver genes such as epidermal growth factor receptor(EGFR) mutation,have been identified as more prevalent in ADC,and tyrosine kinase inhibitors (TKIs) targeting these mutations have greatly improved the prognosis of patients with ADC (Soria et al.,2018).However,driver genes are rarely found in SCC,indicating different origins of these two subtypes of NSCLC.It has been sug-gested that ADCs originate from type Ⅱ alveolar cells and that SCCs originate from bronchial basal cells (Swanton and Govindan,2016;Chen et al.,2021).This hypothesis could better explain why ADC is often peripheral and has a low correlation with smoking,while SCC is always central and strongly correlated with smoking history.