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目的探讨罗格列酮与格列美脲联合用药对2型糖尿病患者血糖控制和降低胰岛素抵抗的作用,为不能坚持按规律进食服药的一组2型糖尿病患者寻找一个既能有效地控制血糖,又能降低胰岛素抵抗,而且依从性好,价格适中的,能够坚持治疗的一种治疗方案。方法我们选取50例因工作繁忙或各种原因不能或者不愿坚持按规律1日3餐进食或常规1日3次服药,而且经济条件中等的2型糖尿病患者,进行罗格列酮与格列美脲联合治疗方案。罗格列酮4mg,1次/d,格列美脲2mg,1次/d,疗程4周,整个疗程中坚持饮食和运动疗法。观察治疗前、后空腹及餐后2h血糖,空腹胰岛素(FINS)和胰岛素抵抗指数(IR),胰岛素敏感指数(ISI)的变化情况。结果50例参与受试者均能坚持治疗,通过各项指标观察,经治疗,患者空腹血糖水平,餐后2h血糖水平、空腹胰岛素水平、胰岛素抵抗指数均有明显降低,而胰岛素敏感指数却有明显升高。结论罗格列酮与格列美脲联合用药,不仅具有明显的降糖效果,且能有效地降低胰岛素抵抗,增加胰岛素敏感性,不失为一种较好的2型糖尿病治疗方案之一。
Objective To explore the effect of rosiglitazone and glimepiride combination on glycemic control and insulin resistance in type 2 diabetic patients and to find out a group of type 2 diabetic patients who can not insist on regular consumption of medication to find an effective way to control blood sugar, But also reduce insulin resistance, and good compliance, affordable, adhere to the treatment of a treatment. Methods We selected 50 cases due to busy work or a variety of reasons can not or do not want to adhere to the law 3 meals a day or routine on the 1st three times a day medication, and the economic conditions of moderate type 2 diabetes, rosiglitazone and Glico The United States urea combination therapy. Rosiglitazone 4mg, 1 time / d, glimepiride 2mg, 1 / d, course of treatment for 4 weeks, insist on diet and exercise therapy throughout the course of treatment. The fasting and postprandial blood glucose, fasting insulin (FINS), insulin resistance index (IR) and insulin sensitivity index (ISI) were observed before and after treatment. Results All the 50 participants were able to adhere to the therapy. Through the observation and treatment of various indexes, the fasting blood glucose level, postprandial 2h blood glucose level, fasting insulin level and insulin resistance index were significantly decreased, while the insulin sensitivity index Significantly increased. Conclusion Rosiglitazone and glimepiride combination therapy, not only has a significant hypoglycemic effect, and can effectively reduce the insulin resistance and increase insulin sensitivity, after all, one of the better treatment of type 2 diabetes.