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目的 探讨溃疡性结肠炎患者肠黏膜组织中部分炎症细胞因子的表达特征以及其对黏膜愈合预后的影响.方法选取收治的102 例活动期溃疡性结肠炎患者(研究组)和100 名健康体检者(对照组)作为研究对象.采用免疫组织化学二步法测定两组肠黏膜组织中的炎性细胞因子(IL-6、IL-11、IL-17、IL-22、IL-23)表达,对比检测结果,并分析各炎性细胞因子表达水平对溃疡性结肠炎患者短期治疗后黏膜愈合预后的影响.结果 研究组肠黏膜组织的IL-6、IL-11、IL-17、IL-22、IL-23表达AOD值均显著高于对照组(P＜0.05).研究组患者经规范化治疗2 个月后,肠黏膜愈合良好53 例,愈合不良49 例.愈合良好组与愈合不良组的一般资料比较显示,性别、年龄、病变累及范围、内镜下活动度分级、疾病活动度、治疗方案的组间差异无统计学意义(P＞0.05).愈合不良组的IL-6、IL-11、IL-22、IL-23高表达率略高于愈合良好组,但组间差异无统计学意义(P＞0.05);愈合不良组的IL-17高表达率显著高于愈合良好组(P＜0.05).结论 炎性细胞因子在溃疡性结肠炎患者肠黏膜组织中的表达明显升高,其中IL-17表达对溃疡性结肠炎患者短期治疗后黏膜愈合预后有一定的预测价值.“,”Objective To investigate the expression of some inflammatory cytokines in intestinal mucosa of patients with ulcerative colitis and its effect on the prognosis of mucosal healing. Methods 102 patients with active ulcerative colitis (study group) and 100 healthy subjects (control group) were selected as objects. The expression of inflammatory cytokines (IL-6, IL-11, IL-17, IL-22, IL-23,) in intestinal mucosa of the two groups was determined by immunohistochemical two-step method. We compared the results and analyzed the effect of inflammatory cytokine expression levels on the prognosis of mucosal healing after short-term treatment in patients with ulcerative colitis. Results The expression of IL-6, IL-11, IL-17, IL-22 and IL-23 in intestinal mucosa of the study group was significantly higher than that of the control group (P＜0.05). After 2 months of standardized treatment in the study group, the intestinal mucosa healed well in 53 cases and the healing was poor in 49 cases. The general data of the well-healed group and the poorly-healed group showed that gender, age, lesion involvement range, endoscopic activity grade, disease activity, and treatment plan were not significantly different between the groups (P＞0.05). The high expression rate of IL-6, IL-11, IL-22 and IL-23 in the poorly-healed group was slightly higher than that in the well-healed group, but the difference between the groups was not significant (P＞0.05). The high expression rate of IL-17 in the poorly-healed group was significantly higher than the well-healed group (P＜0.05). Conclusion The expression of inflammatory cytokines in intestinal mucosa of patients with ulcerative colitis is significantly increased. The expression of IL-17 has a certain predictive value for the prognosis of mucosal healing in patients with ulcerative colitis after short-term treatment.