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目的:总结肝癌微创治疗前后(化疗栓塞术、氩氦冷冻、射频消融等)机体T淋巴细胞亚群变化特点,探讨其对机体免疫功能的影响。方法:应用PubMed和万方等数据检索系统,以“微创治疗、T淋巴细胞亚群”等为关键词,检索2005-01-2011-12的相关文献,纳入标准:1)微创治疗肝癌;2)T淋巴细胞亚群发生免疫功能变化的研究。纳入符合标准的13篇相关文献分析。结果:微创治疗肝癌临床上与手术切除不同之处在于治疗后肿瘤是在体内被灭活,体内坏死的肿瘤组织诱导机体自身抗肿瘤免疫产生,大量研究证实术后CD3+、CD4+、CD4+/CD8+均升高,而CD8+降低,活化T细胞亚群增多,机体免疫功能增强,预后明显得到改善。结论:有效评估微创治疗后肝癌患者的细胞免疫功能水平,为联合免疫治疗在内以介入微创治疗为主的肝癌综合治疗提供理论依据。
Objective: To summarize the characteristics of T lymphocyte subsets in patients with liver cancer before and after minimally invasive treatment (chemoembolization, argon-helium cryoablation, radiofrequency ablation and so on), and to explore their effects on immune function. Methods: Using PubMed and Wanfang data retrieval system, with “minimally invasive treatment, T lymphocyte subsets” as the key words, retrieved the relevant literature from January 2005 to December 2011, including the following criteria: 1) minimally invasive Treatment of liver cancer; 2) T lymphocyte subsets immune function changes. Included in the standard of 13 related literature analysis. Results: The difference between the minimally invasive treatment of hepatocellular carcinoma and surgical resection is that the tumor is inactivated in vivo and the necrotic tumor tissue induces the self anti-tumor immunity in vivo. A large number of studies have confirmed that postoperative CD3 +, CD4 +, CD4 + / CD8 + Were increased, while CD8 + decreased, activated T cell subsets increased, the immune function increased, the prognosis was significantly improved. Conclusions: Effective assessment of cellular immune function in patients with liver cancer after minimally invasive treatment provides a theoretical basis for the comprehensive treatment of hepatocellular carcinoma based on interventional minimally invasive treatment for combination immunotherapy.