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替硝唑(TinidazoieTNZ)为美国60年代开发的硝基咪唑类衍生物,是疗效高、疗程短、耐受性好的抗滴虫和厌氧菌药。我国90年代初研制成功替硝唑,并广泛用于抗滴虫和厌氧菌的治疗,取得了明显疗效[1,2],但替硝唑在临床治疗牙周炎的过程中,仍发现不少病人有消化道和神经系统等
Tinidazoie TNZ is a nitroimidazole derivative developed in the United States in the 1960s. It is a high efficacy, short course of treatment and good tolerance to trichomoniasis and anaerobic bacteria. Tinidazole was successfully developed in China in the early 1990s, and is widely used in the treatment of trichomoniasis and anaerobic bacteria. Obvious effects have been achieved [1, 2]. However, tinidazole is still found in clinical treatment of periodontitis Many patients have gastrointestinal and nervous system