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应用石蜡切片免疫组织化学方法，检测了p53在112例人大肠息肉中的表达，其中26例为腺癌癌变。71例腺癌中3例（4％）P53表达阳性。增生性息肉和轻度不典型增生腺瘤53表达均为阴性。p53表达随腺癌不典型增生程度的不断加重而增强。腺瘤癌变时表达率升高达88％（P＜0．001）。绒毛状腺癌的p53表达率显著增高（p＜0．05）。结果表明在大肠肿瘤形成过程中p53基因实变的作用在良性腺瘤转变为癌的阶段，可能在腺瘤恶变中起关键作用。故p53的检测时判断腺瘤的癌变倾向有重要意义，能辅助临床病理诊断，早期发现大肠癌．
Paraffin section immunohistochemical method was used to detect the expression of p53 in 112 cases of human colorectal polyps, of which 26 cases were cancerous of adenocarcinoma. Three of the 71 adenocarcinomas (4%) had positive P53 expression. Hyperplastic polyps and mild atypical hyperplasia 53 were negative. The expression of p53 increased with the increasing severity of adenocarcinoma atypical hyperplasia. The rate of expression of adenomas increased by 88% (P<0.001). The rate of p53 expression in villous adenocarcinoma was significantly higher (p<0.05). The results indicate that the effect of p53 gene consolidation during the development of colorectal neoplasms is at the stage of conversion of benign adenoma to carcinoma, and may play a key role in the malignant transformation of adenomas. Therefore, the detection of p53 is of great significance in judging the tendency of canceration of adenomas. It can assist clinical pathological diagnosis and early detection of colorectal cancer.