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目的探讨胃食管反流病 (gastroesophageal reflux disease,GERD)患者的胃排空率，对饱胀、饥饿感知敏感性，及胃排空速度对感知的影响。方法临床诊断的 15例 GERD病人和 17例对照者采用核素法测定胃液体、固体排空功能，并记录试餐前后饱胀、饥饿计分。结果 GERD组平均胃液体和固体半排空时间显著长于对照组： GERD组在空腹时有较高的饱胀计分和较低的饥饿计分，随着胃排空延迟，餐后 GERD组饱胀计分下降和饥饿计分上升较对照组缓慢。结论 GERD病人存在胃液体、固体排空延迟；对饱胀、饥饿感知敏感性增加；胃排空速度影响对饱胀、饥饿的感知。
Objective To investigate the effects of gastric emptying rate, sensitivities to fullness and hunger, and gastric emptying rate on the patients with gastroesophageal reflux disease (GERD). Methods Fifteen patients with GERD and 17 controls were enrolled in the study. The radionuclide and fluid emptying function was measured by radionuclide method. The scores of fullness and hunger before and after the test were recorded. Results The average gastric fluid and solid half-emptying time in GERD group was significantly longer than that in control group. GERD group had higher fullness score and lower hunger score at fasting time. With delayed gastric emptying and postprandial GERD group Swelling score decreased and hunger score increased more slowly than the control group. Conclusion Gastric fluid is present in GERD patients, and the emptying of the solid is delayed; the sensitivity to fullness and hunger is increased; and the rate of gastric emptying affects the perception of fullness and hunger.