自1985年来。已经认识到由β_2—微球蛋白(β_2m)多聚体组成的淀粉样纤维为长期血透患者的一种病理过程.这种淀粉样变性命名为Aβ_2m,它伴有一群症状和体征,包括腕管综合征(CPS),弥漫性关节病、溶骨损害、病理性骨折、软组织肿胀和偶有肌臆断裂的肌腱炎。典型者的症状发生在维持透析5年以上。Aβ_2m常不能及时诊断,而需组织活检。其发病机理及有效治疗尚待阐明。 Since 1985 It has been recognized that amyloid fibrils consisting of multimers of β_2-microglobulin (β_2m) are a pathological process in long-term hemodialysis patients, and this amyloidosis is named Aβ_2m and is accompanied by a group of symptoms and signs including the wrist Tubal syndrome (CPS), diffuse arthropathy, osteolytic lesions, pathologic fractures, soft tissue swelling and tendonitis with occasional muscular cleavage. The typical symptoms occur in maintaining dialysis for more than 5 years. Aβ_2m often can not diagnose in time, but need to organize biopsy. The pathogenesis and effective treatment yet to be clarified.