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本文研究了环核苷酸和免疫刺激剂对于葡萄球菌和其他机会病原体被小鼠中性粒细胞和巨噬细胞吞噬的影响。所用葡萄球菌系对小鼠致病力强的Smith氏弥散型菌株,以2.5×10~3个细菌攻击小鼠使80%感染小鼠死亡。该株具有荚膜在小鼠腹腔中不易被吞噬细胞吞噬。取4—6周龄一组小鼠给每只10mg双丁酰腺苷酸或20ng霍乱毒素然后再用葡萄球菌株腹腔注入,由于受上述药物或毒素的作用,小鼠腹腔内cAMP浓度升高而降低了抵抗力,故该组小鼠比对照组(不用任何药物)死亡率高。如事先换用8溴环鸟苷酸
This article investigates the effect of cyclic nucleotides and immunostimulants on the phagocytosis of murine neutrophils and macrophages by staphylococci and other opportunistic pathogens. Staphylococcus aureus was used to kill 80% of mice infected with 2.5% of bacteria that attacked mice with strong virulence. The strain has a capsule that is not easily swallowed by phagocytes in the abdominal cavity of mice. A group of 4-6 weeks old mice were given intraperitoneal injection of 10 mg of dibutyryl adenosine or 20 ng of cholera toxin and then intraperitoneally injected with Staphylococcus aureus strains. Due to the above drugs or toxins, intraperitoneal cAMP concentration increased Which reduces the resistance, so the group of mice than the control group (without any drug) mortality is high. Such as prior to use 8 brominated cyclic guanosine acid