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目的:研究不同干燥工艺制备的金翘热毒清颗粒和金翘热毒清喷雾干燥粉的抗炎作用。方法:将84只小鼠随机分为模型组,阿司匹林组(0.2 g·kg-1),热毒平颗粒组(21.84 g·kg-1),金翘热毒清颗粒组(11.7 g·kg-1),金翘热毒清喷雾干燥粉组(5.85,11.7,23.4 g·kg-1),每组12只,用二甲苯致炎,测定小鼠耳廓肿胀度;另取84只小鼠按上述方法分组和给药,腹腔注射冰乙酸致炎,于590 nm处测定腹腔液吸光度。评价不同干燥工艺制备的金翘热毒清制剂的抗炎作用。结果:模型组,金翘热毒清喷雾干燥粉高、中、低剂量组,金翘热毒清颗粒组,热毒平颗粒组及阳性组小鼠的肿胀度分别为(18.5±3.2),(13.4±2.2),(13.9±3.2),(14.8±3.6),(14.8±2.3),(14.6±4.2),(9.3±2.0)mg,与模型组相比,各给药组动物耳肿胀度均明显降低。模型组,金翘热毒清喷雾干燥粉高、中、低剂量组,金翘热毒清颗粒组,热毒平颗粒组及阳性组的A分别为0.677±0.121,0.512±0.099,0.523±0.137,0.583±0.195,0.537±0.065,0.558±0.107,0.321±0.094。结论:金翘热毒清颗粒和金翘热毒清喷雾干燥粉均具有一定的抗炎作用,可抑制鼠耳肿胀和腹腔毛细血管通透性增高;等剂量金翘热毒清喷雾干燥粉的抗炎作用稍强于金翘热毒清颗粒,等临床倍数剂量的热毒平颗粒的抗炎作用稍弱于金翘热毒清喷雾干燥粉。
OBJECTIVE: To study the anti-inflammatory effects of Jinqiao Renduan Granules and Jinqiao Renduqing Spray Dried Powder prepared by different drying processes. Methods: Eighty-four mice were randomly divided into 4 groups: model group, aspirin group (0.2 g · kg -1), reifuptan group (21.84 g · kg -1), Jinqiao Renduan Granule group -1) and Jinqiao Reiduqing spray-dried powder group (5.85,11.7,23.4 g · kg-1), with 12 in each group. Inflammation with xylene was used to determine the auricular swelling in mice. Another 84 small The rats were grouped and dosed as above, intraperitoneal injection of glacial acetic acid induced inflammation, and the absorbance of peritoneal fluid was measured at 590 nm. To evaluate the anti-inflammatory effects of Jinqiao Renduque preparations prepared by different drying processes. Results: The swelling degree of model group, Jinqiao Renduanqing spray-dried powder in high, medium and low dose groups, Jinqiao Reuthong Granule group, Revinpix Granule group and positive group were (18.5 ± 3.2), (13.4 ± 2.2), (13.9 ± 3.2), (14.8 ± 3.6), (14.8 ± 2.3), (14.6 ± 4.2) and (9.3 ± 2.0) mg, respectively. Compared with the model group, Degree were significantly lower. The A, A and B groups of high, medium and low dose of Jinqiao Re toxinqing spray dry powder, 0.675 ± 0.121,0.512 ± 0.099,0.523 ± 0.137 , 0.583 ± 0.195, 0.537 ± 0.065, 0.558 ± 0.107, 0.321 ± 0.094. CONCLUSION: Jinqiao Rendanqing Granule and Jinqiao Reituqing Spray Dried Powder all have certain anti-inflammatory effect, which can inhibit the eardrum swelling and the increase of peritoneal capillary permeability. The anti-inflammatory effect is slightly stronger than that of Jinqiao Reduqing Granules, and the anti-inflammatory effects of clinical multiple doses of Rendufen Granules are weaker than that of Jinqiao Reiduqing Spray Dried Powder.