Cowen综合征 (CS)或复合错构瘤综合征(MIM)是一种常染色体显性遗传病 ,伴有很高的乳腺癌和甲状腺癌发病风险。 CS的诊断被国际考登协会常规定义为 :当一个患者或者家族具有一组特殊病症的主要的和 /或次要条件时 ,即对 CS进行确诊。 CS基因近来被证实为 PTEN,它位于1 0 q2 3.3 Cowen’s syndrome (CS) or complex hamartoma syndrome (MIM) is an autosomal dominant genetic disease with a high risk of breast and thyroid cancer. The diagnosis of CS is routinely defined by the International Cowden Association as a diagnosis of CS when a patient or family has a primary and / or secondary condition with a particular group of conditions. The CS gene has recently been identified as PTEN, which is located at 10 q2 3.3