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笔者通过从提高片剂的硬度;改善粉体的流动性和防止粉体吸潮结块的作用;油状药物的粉末化;将难溶性结晶药物与硅酸铝镁共同研磨,形成无定型产物,进而提高药物的溶出度;在固体分散制剂以及缓释制剂处方设计的应用等5个方面综述硅酸铝镁在药剂学应用研究的进展,并介绍硅酸铝镁理化特性和安全性评价结果。
The author improves the hardness of the tablet by improving the fluidity of the powder and preventing the powder from absorbing and agglomerating; the powdery oily medicament; the poorly soluble crystal drug and the aluminum magnesium silicate grind together to form an amorphous product, And then improve the dissolution rate of drug. The progress of application of magnesium aluminum silicate in pharmaceutics is reviewed in five aspects, including solid dispersion preparation and formulation design of sustained release preparation. The physical and chemical properties and safety evaluation of magnesium aluminum silicate are also introduced.