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目的 观察中药四君子汤加味对烫伤大鼠肠粘膜和血浆肿瘤坏死因子 (TNF) ,一氧化氮 (NO)和丙二醛 (MDA)含量的影响。方法 用大鼠 70只 ,复制大鼠烫伤模型 ,随机分为 3组 ,烫伤治疗组于伤后 12h开始管饲中药煎剂 ,每 12h 1次至动物活杀 ,烫伤对照组和假伤组管饲蒸馏水 ,于饲药后 3、5、7、9d活杀 ,分别检测血浆和肠粘膜TNF、NO和MDA含量。结果 中药四君子汤加味可明显降低烫伤大鼠血浆和肠粘膜TNF、NO和MDA含量。结论 中药四君子汤加味对减轻烫伤后肠粘膜的损伤应有积极的应用。
Objective To observe the effects of Sijunzi Decoction on the intestinal mucosal and plasma levels of tumor necrosis factor (TNF), nitric oxide (NO) and malondialdehyde (MDA) in scalded rats. Methods A total of 70 rats were used to replicate the scald model in rats and randomly divided into 3 groups. The scald treatment group began to infuse the traditional Chinese medicine decoction at 12 hours after injury, and every 12 hours to live kill, scald control group and false injury group tube. Distilled water was fed and killed at 3, 5, 7 and 9 days after feeding. Plasma and intestinal mucosal levels of TNF, NO and MDA were measured. Results The herbal medicine Sijunzi decoction can significantly reduce the content of TNF, NO and MDA in plasma and intestinal mucosa of scald rats. Conclusion The application of Sijunzi Decoction to alleviate the injury of intestinal mucosa after scald should be actively applied.