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趋化因子 (chemokine)是一类一级结构相似 ,主要对白细胞具有化学趋化作用等多种生物学效应的小分子蛋白 ,在机体的防御和炎症反应等方面起着重要的调节作用。由于其广泛的细胞来源和生物学效应 ,趋化因子及其受体可能在多种疾病的发生和发展中起着重要的作用。在包括系统性红斑狼疮 (systemiclupuserythematosus,SLE)在内的自身免疫性疾病、HIV感染、心血管疾病、过敏性疾病、神经系统炎性疾病、肿瘤等方面的作用越来越引起关注。本文着重对趋化因子在SLE发生发展中的作用作一综述。
Chemokine is a kind of small molecule protein with similar primary structure and mainly has many biological effects such as chemotaxis on leukocytes. It plays an important regulatory role in body defense and inflammatory response. Chemokines and their receptors may play important roles in the development and progression of various diseases due to their extensive cellular and biological effects. The role of autoimmune diseases, including systemic lupus erythematosus (SLE), HIV infection, cardiovascular diseases, allergic diseases, neurological inflammatory diseases, tumors and the like, is drawing more and more attention. This article focuses on the role of chemokines in the development of SLE.