我们过去和最近的工作发现,La~(3+)和Pr~(3+)不但本身有较强的镇痛作用,而且协同电针镇痛,其性质与吗啡相似,都能被Ca~(3+)或纳洛酮对抗。镧系元素有15种,它们的理化性质非常相似,推测其它镧系元素可能也有类似的镇痛特性。为此,本文进一步观察了镧系元素与二价阳离子的相互关系,并着重比较了镧系元素Tb~(3+)、Pr~(3+)、EGTA、吗啡和电针的镇痛效果。 Our past and recent work found that La ~ (3+) and Pr ~ (3+) not only have their own strong analgesic effect but also cooperate with electroacupuncture analgesia and their properties are similar to those of morphine, 3+) or naloxone. There are 15 lanthanides and their physico-chemical properties are very similar, suggesting that other lanthanides may have similar analgesic properties. Therefore, we further observed the relationship between lanthanides and divalent cations, and compared the analgesic effects of lanthanides Tb ~ (3 +), Pr ~ (3 +), EGTA, morphine and electroacupuncture.