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观察了22例心律失常患者,在乙胺碘呋酮治疗前和治疗中,测定血清T_3、T_4和反T_3的浓度变化。从本组病例的结果发现口服乙胺碘呋酮引起血清反T_3水平的升高。服药前的浓度是43.2±9.8ng/dl,服药二周后血清反T_3升至74.5±11.7ng/dl,服药二个月后升至102.6±23.4ng/dl。认为,长期服药患者其反T_3水平在50～100ng/dl之间为安全疗效水平;反T_3浓度持续在100ng/dl以上时,可见临床中毒症状。根据反T_3水平结合临床调节用药。因此,测定血清反T_3指导临床用药,用于监测毒副作用的指标。
Twenty-two patients with arrhythmia were observed, and serum concentrations of T 3, T 4 and anti-T 3 were measured before and during amiodarone treatment. From the results of this group of patients found that oral amiodarone caused serum anti-T_3 level increased. The concentration before taking medicine was 43.2 ± 9.8ng / dl. After two weeks of taking the medicine, the serum anti-T_3 increased to 74.5 ± 11.7ng / dl and rose to 102.6 ± 23.4ng / dl after two months. That long-term anti-T_3 patients in the anti-T_3 levels between 50 ~ 100ng / dl for the safety efficacy level; anti-T_3 concentration continued at 100ng / dl above, we can see clinical symptoms of poisoning. According to the anti-T_3 level combined with clinical regulation medication. Therefore, the determination of serum anti-T_3 to guide the clinical use of drugs for monitoring indicators of toxicity.