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1968年Miller等首次发现1例反复感染的病例：患儿表现为持续腹泻,反复皮肤感染,最终因严重败血症而死亡。实验室检查发现,患儿的血浆不能调理热灭活的酵母菌。此后,人们注意到某些儿童或成人不明原因反复感染,如慢性腹泻、中耳炎、皮肤脓肿以及带状疱疹等的感染的发生与机体缺乏某些不依赖抗体的调理因素有关。经进一步研究,先后从鼠和兔的肝、血浆以及人血清中分离出特异性结合酵母甘露聚
1968, Miller and other for the first time found a case of recurrent infections: children showed persistent diarrhea, repeated skin infections, and eventually died of severe sepsis. Laboratory tests found that children’s plasma can not heat-inactivated yeast. Since then, it has been noticed that some children or adults have unexplained recurrent infections, such as chronic diarrhea, otitis media, skin abscesses, and herpes zoster infections that are associated with the absence of some antibody-independent conditioning in the body. After further study, we have isolated from mammalian and rabbit liver, plasma and human serum specifically binding yeast mannan