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目的:探讨坎地沙坦联合卡托普利治疗糖尿病肾病的临床疗效。方法:将100例糖尿病肾病患者随机分为实验组和对照组各50例,对照组给予卡托普利治疗,实验组在此基础上加用坎地沙坦。对比两组患者收缩压(SPB)、舒张压(DBP)、尿蛋白排泄率(UAER)、肾小球滤过率(GFR)的变化情况,并观察不良反应。结果:经治疗,两组患者的SPB、DBP、UAER、GFR均有所改善,但实验组疗效明显优于对照组(P<0.05)。结论:坎地沙坦联合卡托普利治疗糖尿病肾病疗效满意,可显著降低血压,减轻肾脏损害。
Objective: To investigate the clinical efficacy of candesartan in combination with captopril in the treatment of diabetic nephropathy. Methods: One hundred patients with diabetic nephropathy were randomly divided into experimental group and control group, 50 cases each. The control group was treated with captopril. The experimental group was given candesartan on this basis. The changes of systolic blood pressure (SPB), diastolic blood pressure (DBP), urinary protein excretion rate (UAER) and glomerular filtration rate (GFR) were compared between the two groups. Adverse reactions were observed. Results: After treatment, SPB, DBP, UAER and GFR in both groups were improved, but the experimental group was significantly better than the control group (P <0.05). Conclusion: Candesartan combined with captopril is effective in treating diabetic nephropathy, which can significantly lower blood pressure and reduce renal damage.