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目的探讨CT引导下氩氦冷冻治疗高龄周围型肺癌的安全性、可行性及近期疗效。方法对19例高龄周围型肺癌患者行CT引导下氩氦冷冻治疗,随访观察治疗后3、6、12、24个月时肿瘤变化,统计肿瘤局部控制率和患者生存率。结果治疗后3、6、12、24个月病灶控制有效率(RR)分别为:100%(19/19)、94.7%(18/19)、89.5%(17/19)、84.2%(16/19);19例患者均顺利完成手术,手术过程安全,未出现严重并发症,其中气胸1例,少量咯血或痰中带血2例,胸腔积液1例,术后发热3例;治疗后3、6、12、24个月患者生存率分别为100%(19/19)、100%(19/19)、89.5%(17/19)、84.2%(16/19)。结论 CT导引下经皮穿刺氩氦冷冻治疗高龄周围型肺癌,操作安全,并发症少,近期疗效可靠,可重复进行。
Objective To investigate the safety, feasibility and short-term curative effect of cryogenic argon-helium cryoablation for advanced peripheral lung cancer under CT guidance. Methods Twenty-nine elderly patients with peripheral lung cancer underwent CT-guided cryoablation. The tumor changes at 3, 6, 12, and 24 months after operation were observed. The local tumor control rate and patient survival rate were calculated. Results After 3, 6, 12 and 24 months of treatment, the effective rate of control (RR) was 100% (19/19), 94.7% (18/19), 89.5% (17/19) and 84.2% / 19). All of the 19 patients completed the operation smoothly and had no serious complications. One case had pneumothorax, two cases had hemoptysis or bloody sputum, one case had pleural effusion and 3 cases had postoperative fever. The survival rates at 3,6,12,24 months were 100% (19/19), 100% (19/19), 89.5% (17/19) and 84.2% (16/19) respectively. Conclusion CT-guided percutaneous argon-helium cryoablation of elderly patients with peripheral lung cancer, safe operation, fewer complications, the recent curative effect is reliable and can be repeated.