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细胞免疫治疗肿瘤的效果取决于肿瘤部位辅助细胞和细胞毒细胞的功能。CD_4~+辅助T细胞(Th细胞)在T、B淋巴细胞的免疫调节中起重要作用,它对肿瘤特异性CD_8~+细胞毒淋巴细胞(CTL)的影响,在癌症病人的免疫调节中又起有重要作用。鼠的CD_4~+肿瘤浸润淋巴细胞(TIL)根据它所产生的细胞因子分成不同亚群;Th_n细胞产生IL-2、IL-4和γ-干扰素;Th_1细胞产生IL-2和γ-干扰素;Th_2分泌IL-4、IL-5、IL-6和IL-10。Th_1细胞介导细胞免疫和炎症反应,Th_2细胞支持体液免疫反应。最近又
The effectiveness of cellular immunotherapy for tumors depends on the function of helper cells and cytotoxic cells at the tumor site. CD_4~+ helper T cells (Th cells) play an important role in the immune regulation of T and B lymphocytes, and its effect on tumor-specific CD_8~+ cytotoxic lymphocytes (CTL), and in immune regulation of cancer patients Plays an important role. CD_4~+ tumor infiltrating lymphocytes (TIL) of mice were divided into different subpopulations based on the cytokines it produced; Th_n cells produced IL-2, IL-4 and γ-interferon; Th_1 cells produced IL-2 and γ-interference Th2 secretes IL-4, IL-5, IL-6 and IL-10. Th_1 cells mediate cellular immunity and inflammatory responses, and Th_2 cells support humoral immune responses. Recently