根据化学结构,细胞电生理学特性以及整体心脏的电生理学特点,过去20多年已提出了多种抗心律失常药物的分类方法。然而,其中的许多方法对药物临床应用没有帮助作用,并在临床医师和研究人员中引起相当程度的争论。 抗心律失常药物的分类仅在近来变得更为需要。本世纪30—40年代奎尼丁是防治风湿性心脏病患者的心房纤颤唯一可以应用的药物。普鲁卡因酰 Over the past two decades, a variety of antiarrhythmic drug classifications have been proposed based on chemical structure, cellular electrophysiological properties, and the overall electrophysiological characteristics of the heart. However, many of these methods do not contribute to the clinical use of the drug and have caused considerable controversy among clinicians and researchers. Antiarrhythmic drug classifications have only become more desirable in the recent past. Quinidine in the 30s and 40s of this century is the only drug for the prevention and treatment of rheumatic heart disease in patients with atrial fibrillation. Procaine