目的探讨激素替代治疗卵巢早衰患者的左心功能变化。方法回顾性分析2008年1月至2010年12月省一院接受克龄蒙治疗的卵巢早衰患者24例的临床资料。将24例患者与正常育龄妇女24例作为对照组,运用超声心动图仪测量FS、EF、SV、CO及CI等指标。结果激素替代治疗一年后,左心功能指标治疗组与正常对照组差异无统计学意义。(P>0.05)。结论卵巢功能衰退妇女体内低雌激素水平状态下,心脏功能发生不利变化。当补充外源性雌激素作替代疗法时,其心功能得到明显改善。卵巢早衰患者应在医生指导下考虑尽早进行激素替代治疗,减少女性心血管终点事件的过早发生。 Objective To investigate the changes of left ventricular function in hormone replacement therapy for premature ovarian failure. Methods The clinical data of 24 patients with premature ovarian failure who received gram-ling treatment from January 2008 to December 2010 were retrospectively analyzed. Twenty-four patients and 24 healthy women of childbearing age were used as control group. The indexes of FS, EF, SV, CO and CI were measured by echocardiography. Results After one year of hormone replacement therapy, there was no significant difference between the left heart function therapy group and the normal control group. (P> 0.05). Conclusions Women with ovarian failure have adverse changes in cardiac function in women with low estrogen levels. When supplemented with exogenous estrogen as an alternative therapy, its cardiac function has been significantly improved. Patients with premature ovarian failure should be considered under the guidance of a doctor as soon as possible hormone replacement therapy to reduce the premature occurrence of cardiovascular events in women.