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目的 研究脑梗死 (CI)患者血清可溶性细胞间粘附分子 (sICAM 1)浓度的变化及其临床意义。方法采用双抗体ELISA法测定 10 0例CI患者不同病程血清中sICAM 1的含量 ,并与 30例正常人对照。结果CI患者急性期血清sICAM 1浓度明显高于对照组 (P <0 .0 1) ,在发病后 7天内明显升高 ,7～ 14天内逐渐下降 ,2 1天后逐渐恢复正常。大梗死灶组患者血清sICAM 1的浓度明显高于中梗死灶组和小梗死灶组。CI合并糖尿病患者血清sICAM 1浓度明显高于无合并糖尿病患者。结论 sICAM 1与CI的发生、发展密切相关 ,深入研究CI后血清sICAM 1含量的变化有重要的临床价值
Objective To study the changes of serum soluble intercellular adhesion molecule (sICAM 1) in patients with cerebral infarction (CI) and its clinical significance. Methods Serum levels of sICAM 1 in different stages of CI patients were measured by double antibody ELISA and compared with 30 healthy controls. Results The serum level of sICAM 1 in acute phase of CI patients was significantly higher than that of the control group (P <0.01), significantly increased within 7 days after onset, gradually decreased within 7 to 14 days, and returned to normal after 21 days. Serum levels of sICAM 1 in patients with major infarction were significantly higher than those in middle infarction and small infarction. Serum sICAM 1 concentrations in patients with CI complicated with diabetes were significantly higher than those without diabetes. Conclusions sICAM 1 is closely related to the occurrence and development of CI. The further study on the changes of serum sICAM 1 after CI has important clinical value