硝苯吡啶是1,4双氢吡啶衍化物,能阻滞电位依赖性钙通道,并且体外证实有抑制气道平滑肌收缩的作用。在单一剂量研究中证明,硝苯吡啶和其他钙拮抗剂均可抑制组胺和乙酰甲胆碱诱发的支气管收缩。作者研究了硝苯吡啶对抗运动性哮喘(EIA)的剂量反应关系。选择具有EIA 病史的11例轻型患 Nifedipine is a 1,4-dihydropyridine derivative that blocks potential-dependent calcium channels and has been shown to inhibit airway smooth muscle contraction in vitro. In a single dose study, nifedipine and other calcium antagonists were shown to inhibit histamine and methacholine-induced bronchoconstriction. The authors studied the dose-response relationship of nifedipine against exercise-induced asthma (EIA). Eleven patients with mild history of EIA were selected