论文部分内容阅读
地方性克汀病的病因和发病机制是有争论尚待解决的问题。根据现有资料,归纳起来有四种说法,1)胚胎期缺碘病因,2)遗传因素病因,3)自身免疫病因,4)遗传—缺碘病因。胚胎期缺碘胚因的理论目前被较多学者所承认,但否定地方性克汀病的遗传因素的论据,也不十分充分。持肯定和否定遗传因素是地方性克汀病的发病原因,各有依据。我们为了也探讨地方性克汀病的遗传问题,在我院马泰等(1965)(1)对地方性克汀病的遗传问题研究的基础上,在河北省承德市郊地方性克汀病流行区,又进行了一些遗传学项目的调查研究,并复习了所能接触到的文献。兹将初步结果和讨论叙述如下。一、家系调查地方性克汀病有明显的家族性,这是支持遗传因素是地方性克汀病病因的重要依据之
The causes and pathogenesis of endemic cretinism are controversial issues that remain to be resolved. According to available information, there are four ways to sum up, 1) causes of iodine deficiency during embryogenesis, 2) etiology of genetic factors, 3) autoimmune etiology, and 4) genetic - causes of iodine deficiency. The theory of embryonic iodine deficiency embryo is recognized by more scholars at present, but it is not enough to negate the genetic factors of endemic cretinism. Positive and negative holding genetic factors is the cause of endemic cretinism, each based on. In order to also investigate the genetic problems of endemic cretinism, on the basis of the study of the genetic problems of endemic cretinism in our hospital, Ma Tai et al (1965) (1), endemic cretinism in the suburbs of Chengde, Hebei Province Area, conducted a number of genetic research projects, and reviewed the available literature. The preliminary results and discussion are described below. First, the pedigree investigation of endemic cretinism has obvious familial, which is to support genetic factors is an important basis for the local cretinism