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目的 评价宫内妊娠合并输卵管间质部妊娠(interstitial heterotopic pregnancy,IHP)腹腔镜手术治疗的效果及妊娠结局.方法 回顾性分析了2011年1月至2015年12月期间,在北京大学第三医院生殖医学中心接受体外受精-胚胎移植(In Vitro Fertilization and Embryo Transfer IVF-ET)技术后发生IHP的患者中,经过腹腔镜下输卵管间质部妊娠病灶切开、绒毛组织清除、残腔内壁电凝和宫角缝合治疗的18名患者的临床资料及宫内妊娠结局.结果 18例患者中9例输卵管间质部妊娠病灶破裂,其中6例病变侧的输卵管已切除.平均手术时间(62.1±16.4) min,术中术后无并发症发生.2例分别于孕35周及孕36周早产,余16例均足月分娩.妊娠期间、分娩过程中及剖宫产术中均未发现持续性异位妊娠及子宫破裂.结论 早期腹腔镜手术治疗宫内妊娠合并输卵管间质部妊娠是安全可行的.既往有患侧输卵管切除术史的患者更易发生病灶破裂.“,”Objective To investigate the clinical efficacy of laparoscopic treatments for women with interstitial heterotopic pregnancy(IHP) after in vitro fertilization and embryo transfer(IVF-ET),and the obstetric outcomes.Methods The women who had IHP after fresh or frozen-thawed embryo transfer were retrospectively studied,and they were all treated with laparoscopic surgery at the Center for Reproductive Medicine of Peking University Third Hospital from January,2011 to December,2015.The laparoscopic surgery was conducted by opening the interstitial pregnancy mass,removing the gestational tissue,electrodessicating the inner wall of interstitial cavity,and suturing the cornual.Patients' genenral conditions,peri-surgical data and pregnancy outcomes were reviewed.Results All the 18 women with the diagnosis of IHP were successfully treated by laparoscopic surgery.Ruptured interstitial pregnancy and internal bleeding were found in 9 cases,and 6 of them had the history of salpingectomy at the same side.The average operating time was (62.1 ± 16.4) minutes,no peri-operative complications.All the 18 patients had live-birth deliveries.Two patients had preterm births at 35-and 36-gestation week separately,and the other 16 patients had full term deliveries.No signs of persistent ectopic pregnancy and uterine rupture were found.Conclusions The laparoscopic technique was feasible and safe for IHP with satisfactory obstetric outcomes.To the patients of interstitial pregnancy with salpingectomy history,more attention should be paid and earlier intervention should be taken to prevent the ectopic pregnancy rupture.