心力衰竭的特征是心功能逐渐恶化。近年来,一些小的生物分子-细胞因子,如肿瘤坏死因子-α、白细胞介素1β、白细胞介素6、白细胞介素10、白细胞介素-18、核因子-κB、Fas配基、单核细胞趋化蛋白1、C-反应蛋白等在心力衰竭中的作用越来越引起人们的注意。很多研究表明,这些细胞因子加速了心力衰竭的进程,它们是心力衰竭患者死亡的独立预测因子。在这篇综述里,概述了在心力衰竭的发展过程中细胞因子的重要性、表达及其机制。 Heart failure is characterized by progressive deterioration of cardiac function. In recent years, some small biological molecules - cytokines such as tumor necrosis factor-alpha, interleukin 1 beta, interleukin 6, interleukin 10, interleukin-18, nuclear factor-kappa B, Fas ligand, The role of nuclear chemotactic protein 1, C-reactive protein in heart failure is drawing more and more attention. Numerous studies have shown that these cytokines accelerate the progression of heart failure and are independent predictors of death in patients with heart failure. In this review, the importance, expression, and mechanisms of cytokines in the development of heart failure are outlined.