Objective: To investigate the recurrent patterns and factors involved in node-negative advanced gastric cancer after curative resection.Patients and Methods: Clinicopathological characteristics and prognostic outcomes of 310 patients who had lymph node-negative advanced gastric adenocarcinoma and Received curative resection between 2002 and 2006 were retrospectively evaluated.Results: Among the 300 patients,15(5.0%)had locoregional recurrence,5(1.7%)had lymph node recurrence,27(9.0%)had peritoneal seeding recurrence,and 21(7.0%)had hematogenous metastasis.Using multivariate analysis,we found that the maximum tumor diameter(P=0.014),histological type(P=0,001)and Borrmann type(P=0.033)were independent factors predicting the locoregional recurrence.Lymph node recurrence was significantly affected by lymph node dissection(P=0.029)and lymphovascular invasion(P=0.004).Clinicopathological factors predicting the peritoneal seeding recurrence were the depth of invasion(P=0.001)and Borrmann type(P=0.002).In addition,lymphovascular invasion(P=0.013)and histological type(P=0.001)were significantly associated with hematogenous metastasis.Conclusion: Node-negative advanced gastric cancer has a high amount of peritoneal seeding and hematogenous metastasis.