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目的:探讨布地奈德联合特布他林雾化液雾化吸入治疗小儿毛细支气管炎的临床疗效。方法:选择该院2007年3月～2010年3月收治的72例住院毛细支气管炎患儿作为观察对象,根据治疗方法的不同随机分为治疗组和对照组各36例,两组均常规给予抗感染、化痰、静滴地塞米松0.2 mg.kg-1.d-1,每天1次,双肺喘鸣音消失后改为口服强的松0.75 mg.kg-1.d-1,每天3次,同时予吸氧、镇静、补液、营养支持等治疗,治疗组在常规治疗基础上给予生理盐水1 ml/次+布地奈德雾化液0.5 mg/次+特布他林雾化液2.5 mg/次(阿斯利康有限公司生产)氧气驱动雾化吸入,氧流量为6～8 L/min,5～10 min/次,每天2次,雾化至临床症状、体征消失。比较两组的疗效及临床症状体征改善情况。结果:治疗组有效率为94.44%,对照组有效率为83.33%,两组患者疗效及有效率比较差异有统计学意义(P<0.05)。全部患者未见明显的不良反应。治疗组咳嗽、喘憋、喘鸣音及肺部啰音的消失时间明显短于对照组,且住院时间也短于对照组(P<0.05)。结论:布地奈德、特布他林溶液联合雾化吸入治疗小儿毛细支气管炎疗效确切,可以明显改善患者的临床症状,缩短住院时间,安全无痛苦,小孩易接受,值得临床推广。
Objective: To investigate the clinical efficacy of budesonide combined with terbutaline in aerosol inhalation in the treatment of pediatric bronchiolitis. Methods: A total of 72 hospitalized patients with bronchiolitis admitted to our hospital from March 2007 to March 2010 were selected and randomly divided into treatment group (36 cases) and control group (36 cases). The patients in both groups were routinely given Anti-infective, phlegm, intravenous dexamethasone 0.2 mg.kg-1.d-1, 1 day, wheezing of wheezing changed to oral prednisone 0.75 mg.kg-1.d-1, 3 times a day, at the same time to oxygen, sedation, rehydration, nutritional support and other treatment, the treatment group on the basis of routine treatment given saline 1 ml / time + budesonide aerosol 0.5 mg / times + terbutaline atomization Liquid 2.5 mg / time (manufactured by AstraZeneca Co., Ltd.) Oxygen-driven atomization inhalation, oxygen flow of 6 ~ 8 L / min, 5 ~ 10 min / times, 2 times a day, nebulized to clinical symptoms, signs disappear. The curative effect and improvement of clinical symptoms and signs were compared between the two groups. Results: The effective rate of the treatment group was 94.44%, while that of the control group was 83.33%. There was significant difference between the two groups in curative effect and effective rate (P <0.05). All patients showed no obvious adverse reactions. The disappearance time of cough, wheezing, wheezing and pulmonary rales in the treatment group was significantly shorter than that in the control group, and the length of stay in the treatment group was also shorter than that in the control group (P <0.05). Conclusion: The combination of budesonide and terbutaline solution combined with atomization inhalation for the treatment of pediatric bronchiolitis has definite curative effect, which can significantly improve the clinical symptoms, shorten the length of hospital stay, be safe and painless, and it is worthy of clinical promotion.