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Ver,Nef和Tet抑制WKY和SHR的左心室乳头状肌和门静脉的收缩。Tet抑制SHR门静脉的IC_(50)比WKY高近10倍,分别为237和27μmol·L~(-1),提示SHR的门静脉对Tet的反应性降低。Ver,Nef和Tet对WKY的血管选择性(抑制乳头状肌IC_(50)与抑制门静脉IC_(50)之比)分别为1.15,0.32和0.20,对SHR分别为0.80,0.24和0.10,说明Ver对心肌和血管缺乏选择性抑制,Nef和Tet较易抑制心肌。
Ver, Nef and Tet inhibit WKY and SHR contraction of the left ventricular papillary muscle and portal vein. The IC50 of Tet inhibition in SHR portal vein was nearly 10 times higher than that of WKY, which were 237 and 27 μmol·L-1, respectively, suggesting that the response of portal vein to Tet was reduced in SHR. The vascular selectivity of Ver, Nef, and Tet to WKY (the ratio of IC 50 in inhibiting papillary muscle and IC 50 in inhibiting portal vein) were 1.15, 0.32, and 0.20, respectively, and 0.80, 0.24, and 0.10 for SHR, respectively. In the absence of selective inhibition of myocardial and blood vessels, Nef and Tet are more likely to inhibit the myocardium.