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利用家兔在体心肌缺血模型研究了儿茶酚胺排空、α－受体激动剂和α－受体阻断剂对心肌缺血后心律失常发生率及心肌细胞单相动作电位的影响。结果表明，利血平排空儿茶酚胺及α－受体阻断剂酚妥拉明可明显降低心肌缺血时心律失常的发生率；并使心肌有效不应期和动作电位时程延长；α－受体激动剂甲氧胺则具有相反作用。提示α－受体激动在心肌缺血早期具有重要的致心律失常作用。
The effects of catecholamine emptying, α-receptor agonists and α-blockers on the incidence of post-ischemic arrhythmia and single-phase action potential of cardiomyocytes were studied in a rabbit model of myocardial ischemia. The results showed that reserpine emptying catecholamines and α-receptor blockers phentolamine can significantly reduce the incidence of arrhythmia myocardial ischemia; and myocardial refractory period and action potential duration prolonged; α- The receptor agonist, methoxyamine, has the opposite effect. Tip α-agonist in the early myocardial ischemia has an important cause of arrhythmia.