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艾滋病毒(HIV)感染可加速丙型肝炎病毒(HCV)所致肝病的进展,因此在HCV/HIV重叠感染者中,探索HCV感染的治疗是当务之急。 HCV感染能否改变HIV感染的病程尚有争议。瑞士一项对HIV感染者平均随访28个月的研究证实,HCV血清阳性者进展至临床艾滋病或死亡者增加,尤其多见于严重吸毒的HCV感染者,然而此种存活率降低似乎并非重叠感染者对高效抗逆转录病毒疗法(HAART)的疗效降低所致,因为HCV血清阳性与HIV RNA水平<400拷贝/mL两者并无相关性,但在治疗中,HCV阳性者CD4细胞数的增加确实低于单纯HIV感染者,可能是HCV对淋巴细胞的致病作用而影响HIV相关的免疫功能恢
HIV infection can accelerate the progress of liver disease caused by Hepatitis C virus (HCV), therefore, it is urgent to explore the treatment of HCV infection among HCV / HIV overlap patients. Whether HCV infection can alter the course of HIV infection remains controversial. A Swiss study of an average 28-month follow-up of HIV-infected patients confirms that HCV-seropositive patients have progressed to clinical AIDS or die more often, especially in severely drug-addicted HCV-infected individuals, but this decline in survival does not seem to be overlapping Efficacy of HAART is reduced because there is no correlation between HCV seropositivity and HIV RNA levels <400 copies / mL, but the increase in the number of CD4 cells in HCV-positive patients during treatment is indeed Lower than HIV-infected individuals, may be the pathogenic role of HCV on lymphocytes and affect the immune function associated with HIV