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目的研究阿德福韦酯联合双环醇治疗慢性乙型肝炎的疗效。方法77例慢性乙型肝炎患者随机分为两组,试验组(39例)每日口服阿德福韦酯10mg、双环醇75mg;对照组(38例)每日仅口服阿德福韦酯10mg。两组均连续用药48周。观察治疗前后血清氨基转移酶、病毒学指标、肝脏影像学指标的改变。结果治疗48周后,试验组ALT复常率(87.18%)显著高于对照组(65.79%),HBV-DNA转阴率(64.10%)显著高于对照组(39.47%),影像学指标改善优于对照组,差异均有统计学意义(P<0.05)。结论阿德福韦酯与双环醇联合应用治疗慢性乙型肝炎能取得更好的生化学应答、病毒学应答和影像学改善。
Objective To study the curative effect of adefovir dipivoxil combined with bicyclol in the treatment of chronic hepatitis B. Methods A total of 77 patients with chronic hepatitis B were randomly divided into two groups. The experimental group (39 patients) were given oral adefovir dipivoxil 10mg and bicyclol 75mg daily. The control group (38 patients) were given oral adefovir dipivoxil 10mg . Both groups were treated for 48 weeks. The changes of serum aminotransferase, virological index and liver imaging index before and after treatment were observed. Results After treatment for 48 weeks, the rate of ALT abnormality (87.18%) in the experimental group was significantly higher than that in the control group (65.79%), the negative rate of HBV DNA (64.10%) was significantly higher than that in the control group (39.47% The difference was statistically significant (P <0.05). Conclusion The combination of adefovir dipivoxil and bicyclol in the treatment of chronic hepatitis B can achieve better biochemical response, virological response and imaging improvement.