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安全有效的疫苗是阻止高致病性(HPAI)禽流感病毒H5N1在人群中大规模暴发的最好方法。目前FDA批准的H5N1疫苗有明显的局限性,因此,迫切需要更加有效的H5N1疫苗问世。副流感病毒5(PIV5)是一种副黏病毒,在人群中不引起任何疾病,因此是一种可行的疫苗载体。在我们的研究中,用单剂量的表达有来自一H5N1亚型病毒血凝素(HA)的重组活PIV5(rPIV5-H5)免疫小鼠,发现对致死剂量的HPAI H5N1攻击具有免疫作用。另外,
A safe and effective vaccine is the best way to stop the outbreak of H5N1, a bird flu virus of the highly pathogenic (HPAI) virus, in the population. Currently, the H5N1 vaccine approved by the FDA has obvious limitations and there is an urgent need for a more effective H5N1 vaccine. Parainfluenza 5 (PIV5) is a paramyxovirus that does not cause any disease in the human population and is therefore a viable vaccine vector. In our study mice were immunized with a single dose of recombinant live PIV5 (rPIV5-H5) expressing a H5N1 subtype virus hemagglutinin (HA) and found to be immunogenic against lethal doses of HPAI H5N1 challenge. In addition,