论文部分内容阅读
吸入性损伤常伴有不同程度氧运输（DO2）一氧耗量（VO2）依赖状态，本研究旨在评价吸入一氧化氮（NO）在犬烟雾吸入性损伤时对DO2和VO2的影响。17只犬随机分为2组，烟雾吸入后，对照组（n=8）单纯吸氧（FiO2，0.45），治疗组（n=9）吸氮（FiO2，0.45）＋0.0045％（45ppm）NO，连续监测12h动静脉血和心输出量（CO）变化。数据行多个样本均数间方差分析。结果，治疗组DO2和VO2均明显高于对照组（P＜0.05，P＜0.01），治疗组氧摄取率（ERO2）比对照组有不同程度升高，在某些时相点有显著性（P＜0.05），而治疗组动脉血乳酸水平比对照组明显降低（P＜0.05，＜0.01）。吸入NO能不同程度提高DO2、VO2和ERO2，明显降低乳酸水平，具有不同程度摆脱DO2-VO2依赖状态。
Inhalation injury is often accompanied by varying degrees of oxygen demand (DO2) oxygen demand (VO2) -dependent state. This study was designed to evaluate the effects of inhaled nitric oxide (NO) on DO2 and VO2 during canine smoke inhalation injury. Seventeen dogs were randomly divided into two groups. After smoke inhalation, FiO2 (0.45) in the control group (n = 8) and 0.0045% (45ppm) in the treatment group NO, continuous monitoring of 12h arterial blood and cardiac output (CO) changes. Analysis of variance between multiple samples in data rows. Results The DO2 and VO2 in the treatment group were significantly higher than those in the control group (P <0.05, P <0.01). The oxygen uptake rate (ERO2) in the treatment group increased to some extent compared with that in the control group and was significant at some time points P <0.05), while the arterial blood lactate level in the treatment group was significantly lower than that in the control group (P <0.05, <0.01). Inhalation of NO can increase DO2, VO2 and ERO2 to different degrees, significantly reduce the level of lactate, with varying degrees to get rid of DO2-VO2 dependent state.