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据Wang W 2016年8月5日[Nat Med,2016,22(8):869-878.]报道,美国凯斯西储大学(Case Western Reserve University)的研究人员通过研究发现,RNA结合蛋白或许会引发肌萎缩侧索硬化症(ALS)疾病的进展。细胞中的RNA会携带DNA制造蛋白质的指令,研究人员发现了名为TDP-43的罪魁祸首。TDP-43是一种可以结合到新生成的RNA小块碎片上的蛋白质,其可以帮助这些碎片围绕着神经细胞核内部来回穿梭。该研究也首次描述了蛋白
According to Wang W, August 5, 2016 [Nat Med, 2016, 22 (8): 869-878] reported that researchers at Case Western Reserve University in the United States found that RNA-binding proteins may Can cause the development of amyotrophic lateral sclerosis (ALS) disease. The RNA in the cell carries the DNA-making instructions for the protein, and researchers found the culprit, called TDP-43. TDP-43 is a protein that binds to newly formed scrap pieces of RNA that help shuttle these fragments back and forth around the interior of the nerve cell nucleus. The study also describes the protein for the first time