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目的探讨脐带血S100B蛋白对新生儿窒息后脑损伤判断的临床价值。方法采用酶联免疫吸附试验(ELISA)对正常阴道分娩、剖宫产非窒息、异常阴道分娩及剖宫产宫内窒息4个组的新生儿脐带血S100B蛋白含量进行检测并作对比分析。结果异常阴道分娩组及剖宫产宫内窒息组的新生儿脐带血S100B蛋白含量明显高于正常阴道分娩组及剖宫产非窒息组,差异有统计学意义(P<0.01);正常阴道分娩组与剖宫产非窒息组新生儿脐带血Sl00B蛋白含量差别无统计学意义(P>0.05)。结论新生儿脐带血S100B蛋白含量的检测有助于新生儿窒息后脑损伤的判断。
Objective To investigate the clinical value of umbilical cord blood S100B protein in judging brain injury after neonatal asphyxia. Methods Serum levels of S100B in neonates with normal vaginal delivery, non-asphyxiated cesarean section, abnormal vaginal delivery and intrauterine sphincter of cesarean section were detected by enzyme-linked immunosorbent assay (ELISA) and compared. Results The levels of S100B protein in neonates with abnormal vaginal delivery group and intrauterine asphyxia group were significantly higher than those in normal vaginal delivery group and cesarean section non-asphyxia group (P <0.01). Normal vaginal delivery There was no significant difference in umbilical cord blood S100B protein levels between neonates with cesarean section and non-asphyxiated group (P> 0.05). Conclusion The detection of S100B protein in cord blood of neonates is helpful to judge the brain injury after neonatal asphyxia.