论文部分内容阅读
目的:探讨2型糖尿病患者凝血功能及血清肿瘤坏死因子α(TNF-α)及白细胞介素18(IL-18)水平与糖尿病血管病变的关系。方法:选择2014年6月-2015年10月在我院接受治疗的2型糖尿病患者83例作为研究对象,根据患者疾病进展情况将其分为血管病变组(45例)和无血管病变组(38例)。测定两组患者凝血酶时间(TT)、活化部分凝血酶原时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(Fg)、血糖(Glu)、糖化血红蛋白(Hb A1c)、肿瘤坏死因子α(TNF-α)及白细胞介素18(IL-18)水平;采用logistics回归分析2型糖尿病患者发生血管病变的危险因素。结果:血管病变组患者Glu,Hb A1c及Fg水平均显著高于无血管病变组,而APTT及PT水平均显著低于无血管病变组,差异均具有统计学意义(P<0.05);两组间TT水平比较,差异无统计学意义(P>0.05)。血管病变组患者血清中TNF-α及IL-18水平均高于无血管病变组患者,差异具有统计学意义(P<0.05)。Hb A1c,Fg,TNF-α以及IL-18水平异常是2型糖尿病患者发生血管病变的独立危险因素(OR=1.23,1.45,2.632,3.884,P<0.05)。结论:凝血功能紊乱及炎症反应是2型糖尿病患者发生血管病变的重要因素,临床应给予重视。
Objective: To investigate the relationship between coagulation function, serum tumor necrosis factor-α (TNF-α) and interleukin-18 (IL-18) levels and diabetic angiopathy in type 2 diabetic patients. Methods: Totally 83 patients with type 2 diabetes mellitus treated in our hospital from June 2014 to October 2015 were selected as study subjects. According to their disease progression, they were divided into vascular lesion group (n = 45) and non-vascular lesion group 38 cases). Thrombin time (TT), active partial prothrombin time (PTT), prothrombin time (PT), fibrinogen (Fg), Glu, Hb A1c, tumor necrosis (TNF-α) and interleukin-18 (IL-18) were detected by flow cytometry. Logistic regression was used to analyze the risk factors of vascular lesions in type 2 diabetic patients. Results: The levels of Glu, Hb A1c and Fg in patients with vascular disease were significantly higher than those without vascular disease, while the levels of APTT and PT were significantly lower than those without vascular disease (P <0.05). Two groups There was no significant difference between TT levels (P> 0.05). The serum levels of TNF-α and IL-18 in patients with vascular disease were significantly higher than those without vascular disease (P <0.05). Abnormality of Hb A1c, Fg, TNF-α and IL-18 levels were independent risk factors for type 2 diabetes (OR = 1.23,1.45,2.632,3.884, P <0.05). Conclusion: Coagulation dysfunction and inflammatory response are important factors in the development of vascular lesions in patients with type 2 diabetes, and clinical attention should be given.