我们采用氟丁酰胺能有效干扰孕鼠体内雄激素正常生理作用机制的原理,建立了先天性尿道下裂小鼠模型。一、材料与方法1.材料:昆明种小鼠,136只,清洁级,10周龄,雌雄兼用,比例3∶1,购自山西省中医研究院动物室。饲养在YX型实验动物洁净柜中。实验动物环境条件符合GB14925-2001国家 We use the principle that flurbipamide can effectively interfere with the normal physiological function of androgen in pregnant rats and establish a mouse model of congenital hypospadias. Materials and methods 1. Materials: Kunming mice, 136, clean grade, 10 weeks old, both male and female, the ratio of 3: 1, purchased from the Shanxi Provincial Institute of Traditional Chinese Medicine room. Reared in YX laboratory animal clean cabinet. Laboratory animal environmental conditions in line with GB14925-2001 countries