目的分析不同认知功能的老年慢性精神分裂症的临床特征及脑ＣＴ表现。方法比较１５例认知功能缺损的精神分裂症患者与１９例认知功能相对保存的精神分裂症患者的一般情况、临床症状、日常活动能力及脑ＣＴ改变。结果与保存组相比，缺损组教育程度低，女性比例高，起病较慢，起病诱因多，非偏执型比例高，阴性症状较多，日常活动能力下降更显著，脑萎缩明显，统计检验有显著意义。结论认知功能缺损和相对保存的老年慢性精神分裂症很可能具有异源性病因。 Objective To analyze the clinical features and brain CT findings of senile chronic schizophrenia with different cognitive functions. Methods Fifteen schizophrenic patients with cognitive impairment and 19 schizophrenic patients with cognitive impairment were compared for their general condition, clinical symptoms, daily activities and brain CT changes. Results Compared with the preservation group, the education level of the defect group was low, the proportion of women was high, the onset was slow, the cause of onset was more, the proportion of non-paranoid type was higher, the number of negative symptoms was more, the activity of daily activities decreased significantly, and the brain atrophy was obvious. Test has significant meaning. Conclusion Cognitive impairment and relative preservation of elderly chronic schizophrenia are likely to have heterologous causes.