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本实验在自发性高血压大鼠（ＳＨＲ）观察了卡托普利对血压，心肌和主动脉组织ＡＴⅡ，ＥＴ，ＤＡ，ＮＥ的影响。结果表明，ＳＨＲ心肌、主动脉组织ＡＴⅡ、ＥＴ含量显著增加，而ＤＡ、ＮＥ含量则呈消耗性减少。卡托普利治疗能降低ＳＨＲ，心肌、主动脉ＡＴⅡ、ＥＴ含量，增加ＤＡ、ＮＥ含量，同时显著降低大鼠血压。提示卡托普利的降压作用机制可能与抑制心肌、血管组织ＡＴⅡ、ＥＴ、ＮＥ和ＤＡ的生成和释放有关。
In this study, we observed the effects of captopril on blood pressure, myocardium and aorta tissue AT Ⅱ, ET, DA, NE in spontaneously hypertensive rats (SHR). The results showed that the contents of ATⅡ and ET in myocardium and aorta of SHR were significantly increased, while the contents of DA and NE were decreased consumptively. Captopril treatment can reduce SHR, myocardium, aorta AT Ⅱ, ET content, increase DA, NE content, while significantly lower blood pressure in rats. These results suggest that the antihypertensive mechanism of captopril may be related to the inhibition of the production and release of ATⅡ, ET, NE and DA in myocardium and vascular tissue.