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补骨脂素混合结晶中补骨脂素在S_(180)小鼠腹水内属单室模型中呈双峰吸收。其动力学参数如下■l/2(h)为22.19;K_a(h~(-1))为12.3580;K(h-1)为0.0312;tlag(h)为0.0718;C_(max)(μg/ml)为6.3967;t_(max)(h)为0.5570;AUC(μg·h/ml)为175.0300。2亿S_(180)癌细胞内在0.25h时,其补骨脂素含量高达10.97μg/ml,腹水内补骨脂素含量既高且久,有利于肿瘤的冶疗。
Psoralen in psoralen mixed crystals showed bimodal absorption in a single-chamber model in ascites of S_(180) mice. The kinetic parameters are as follows: ■l/2(h) is 22.19; K_a(h~(-1)) is 12.3580; K(h-1) is 0.0312; tlag(h) is 0.0718; C_(max)(μg/ Ml) was 6.3967; t_(max) (h) was 0.5570; AUC (μg·h/ml) was 175.0300. The psoralen content was as high as 10.97 μg/ml when the 200 million S_(180) cancer cells were intrinsic at 0.25 h. The content of psoralen in ascites is high and long, which is beneficial to the treatment of tumors.