本文通过对鼻咽癌患者染色体断裂点、脆性部位与姐妹染色单体互换关系的研究,认为鼻咽癌患者染色体畸变断裂点、脆性部位和SCE无论在发生频率,累及染色体组别,还是在发生部位上都有一定相关。基于它们都反映染色体脆性的良好指标,因此在人群中尤其在某些肿瘤高发区,癌高发家族中进行检测,可能有助于确定肿瘤的起因和易感性,对早期发现癌患者有一定参考价值。 In this paper, nasopharyngeal carcinoma patients with chromosomal breakpoints, brittle parts and sister chromatid exchange relationship that the nasopharyngeal cancer patients with chromosomal aberrations, brittle sites and SCE regardless of the frequency of occurrence, involving the chromosome group, or in Occurred on the site there is a certain correlation. Based on their good indicators of chromosomal fragility, detection in the population, especially in some high-risk areas and high-risk cancers, may help to determine the causes and susceptibility of tumors and provide some reference value for early detection of cancer patients .