The covalently closed circular DNA (cccDNA) of HBV plays a crucial role in viral persistence and is also a risk factor for developing HBV-induced diseases,including liver fibrosis.Stimulator of interferon genes (STING),a master regulator of DNA-mediated i
Chronic inflammation promotes tumor development,progression,and metastatic dissemination and causes treatment resistance.The accumulation of genetic alterations and loss of normal cellular regulatory processes are not only associated with cancer growth an
Decades of advancements in immuno-oncology have enabled the development of current immunotherapies,which provide long-term treatment responses in certain metastatic cancer patients.However,cures remain infrequent,and most patients ultimately succumb to tr
OBJECTIVE;The interleukin (IL)-12 cytokine family is closely related to the development of T helper cells,which are responsible for autoimmune disease enhancement or suppression.IL-12 family members are generally heterodimers and share three α-subunits(p3