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1953年Dillaha等报告用二碘羟基喹啉(二碘喹)或5-氯-7-碘-8-羟喹啉(肠用慰欧仿EV)治疗肠病性肢端皮炎(AE),症状明显缓解。但长期服药偶可发生严重眼损害。1973年Moynahan等用硫酸锌治疗本病取得良好效果。并发现患者的血清锌水平低下,现在认为属遗传性锌吸收缺损病。为阐明此缺损机理,作者检查了患者粪内菌群,观察了服锌的影响,并与EV治疗结果作比较。本文观察了两例自断乳时发病的女性AE患者,分别为15岁和18岁。原用EV治疗,3年前改服硫酸锌,对照组为此二患者之母(45岁和49岁,无病证)及一48岁的健康男性(与本2例家系无遗传联系)。方法:停服硫酸锌两周后,在患者口周、鼻翼部位出现轻度瘙痒性红斑时,连续收集粪便标本二次后,予患者服用硫酸锌每日150mg两或3周,待症状消失后再次取材,对照组取材方法同前。为观察EV的影响,例一于再次取材后,改服EV每日500mg
In 1953, Dillaha et al reported that the treatment of enteric dermatitis (AE) with diiodoquinol (quinolone) or 5-chloro-7-iodo-8-hydroxyquinoline Clearly relieved. However, long-term medication even Occasion serious eye damage. In 1973, Moynahan and other zinc sulfate treatment of the disease achieved good results. And found that patients with low levels of serum zinc, and now consider a genetic zinc deficiency defect. To elucidate the mechanism of this defect, the authors examined the faecal flora of patients and observed the effect of taking zinc and compared it with the results of EV treatment. This article looked at two women with AE who developed spontaneous weaning, aged 15 and 18 years, respectively. The original EV treatment, change clothes three years ago, zinc sulfate, the control group for the two mother (45 years old and 49 years old, disease-free card) and a 48-year-old healthy men (with the two families without genetic contact). Methods: After taking zinc sulphate two weeks later, when mild pruritic erythema occurred on the perioral and nasal parts of the patient, the stool samples were collected continuously for two times. The patients were given 150mg / day of zinc sulfate for two or three weeks. After the symptoms disappeared Draw again, the control group drawn the same way. In order to observe the impact of EV, for example, once again taken after the change service EV daily 500mg