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目的：避免骨髓移植MAC预处理方案中存在的口服马法兰用量大、病人服药困难及吸收剂量不准确。方法：采用全静脉给药MAC预处理方案进行自体骨髓移植2例。结果：发现该方案用量准确、使用方便，但存在着造血恢复时间长、胃肠道损伤重等缺点。结论：该方案能切实保证无照射骨髓移植预处理的效果，可考虑替代口服马法兰作为首选。
OBJECTIVE: To avoid the large dose of oral maltide in the MAC pretreatment regimen for bone marrow transplantation, which makes it difficult for the patient to take the drug and inaccurate the absorbed dose. Methods: Two cases of autologous bone marrow transplantation were performed with total intravenous administration of MAC pretreatment. RESULTS: It was found that the dosage was accurate and convenient to use, but there were shortcomings such as long recovery time of hematopoiesis and heavy damage to the gastrointestinal tract. Conclusion: This protocol can effectively guarantee the effect of non-irradiation bone marrow transplantation pretreatment, and it may be considered as an alternative to oral maflan.