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目的 :探讨急性心肌梗死 ( AMI)患者发病早期至 1周内血清可溶性细胞间黏附分子 1 ( s ICAM1 )、可溶性血管细胞黏附分子 1 ( s VCAM 1 )、D 二聚体 ( D D)、血小板第 4因子 ( PF4 )的动态变化及其相互关系。方法 :测定 4 0例 AMI患者发病 2 4小时和 1周时的血清 s ICAM 1、s VCAM 1、D D、PF4并与健康对照组 3 0例比较。结果 :AMI患者于发病 2 4小时及 1周时 s ICAM 1、s VCAM 1、D D、PF4〔发病 2 4小时分别( 42 0 .97± 1 2 8.83 )μg/L ,( 51 .4 4± 1 4.83 )μg/L ,( 3 57.93± 1 47.0 9)μg/L和 ( 6.1 0± 1 .54 ) mg/L ;发病 1周时分别为 ( 40 4 .96± 1 1 5.2 2 ) μg/L,( 48.0 1± 1 7.2 4 ) μg/L,( 3 81 .1 2± 1 63 .0 0 ) μg/L和 ( 6.3 3± 2 .1 9) mg/L〕均明显高于对照组〔分别为 ( 1 80 .70± 3 2 .0 7)μg/L,( 1 3 .3 1± 1 2 .81 )μg/L ,( 84 .0 0± 2 6.99)μg/L和 ( 3 .0 7± 1 .3 4) mg/L ,P均 <0 .0 1〕。AMI组于发病 2 4小时及 1周时 s ICAM 1与 s VCAM 1均具有正相关性 ( P均 <0 .0 1 ) ,PF4与 s ICAM 1、s VCAM 1、D D间亦具有正相关性 ( P均 <0 .0 1 ) ,而 D D与 s ICAM 1、s VCAM 1间均无相关性 ( P均 >0 .0 5)。结论 :AMI从发病早期至 1周内 s ICAM 1、s VCAM 1持续升高
Objective: To investigate the changes of serum soluble intercellular adhesion molecule 1 (s ICAM1), soluble vascular cell adhesion molecule 1 (s VCAM 1), D dimer (DD) and platelet count in patients with acute myocardial infarction (AMI) Dynamic changes of four factors (PF4) and their correlations. Methods: Serum levels of s ICAM 1, s VCAM 1, D D and PF 4 in 40 AMI patients at 24 hours and 1 week were measured and compared with those in healthy controls. Results: The ICAM 1, s VCAM 1, DD, PF4 in the AMI patients at 24 hours and 1 week of onset [(42 ± 0.97 ± 122.883) μg / L and (51.44 ± 1 4.83) μg / L, (3 57.93 ± 1 47.0 9) μg / L and (6.1 0 ± 1.54) mg / L, respectively; L, (48.0 1 ± 1 7.2 4) μg / L, (3 81.1 ± 1.6 63.0) μg / L and (6.3 3 ± 2.1 9) mg / L] were significantly higher than those of the control group 〔(180 ± 70.2 ± 0.07) μg / L, (± 3.3 ± 1 ± 2.81) μg / L, (84.0 ± ± 2.6) μg / L and .0 7 ± 1 .3 4) mg / L, P <0.01). There was a positive correlation between ICAM 1 and VCAM 1 in AMI group at 24 hours and 1 week of onset (all P <0.01), and there was also a positive correlation between PF4 and ICAM 1, VCAM 1 and DD (All P <0.01), while there was no correlation between DD and s ICAM 1, s VCAM 1 (all P> 0.05). CONCLUSIONS: The ICAM-1 and s VCAM-1 in AMI continuously increased from the early stage to the first week of onset