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以某公路段养路工１７３人为接触组，机关行政人员４０人为对照组，对血清过氧化脂质（ＬＰＯ）、血清唾液酸（ＳＡ）及血清谷胱甘肽硫转移酶（ＧＳＴ）三项生物膜损伤指标进行了检测。结果：养路工血清ＳＡ及ＧＳＴ显著高于对照组（Ｐ＜０．０５，Ｐ＜０．００１），ＬＰＯ未见明显改变。养路工不同工龄间的ＬＰＯ、ＳＡ及ＧＳＴ测定，仅ＧＳＴ随工龄增加而增高（Ｐ＜０．０５）。不同性别间，仅ＧＳＴ男工高于女工（Ｐ＜０．０５）。吸烟对生物膜损伤指标未见明显影响。提示养路工在职业有害因素作用下，生物膜可受到一定损伤。
A total of 173 road maintenance workers were employed as contact group and 40 administrators as control group. Serum lipid peroxidation (LPO), serum sialic acid (SA) and serum glutathione S-transferase (GST) Membrane damage indicators were tested. Results: The serum SA and GST of road maintenance workers were significantly higher than those of the control group (P <0.05, P <0.001), but there was no obvious change of LPO. LPO, SA and GST of maintenance workers in different working age groups, only GST increased with the increase of seniority (P <0.05). Among different genders, only GST male workers were higher than female workers (P <0.05). Smoking had no significant effect on biofilm damage index. Tips road maintenance workers in the role of occupational hazards, biofilms can be some damage.