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目的:研究高脂血症(HLP)患者血清载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)及脂蛋白a(Lipa)水平的变化及它们之间的相互关系,对防止心血管疾病具有十分重要意义。方法:120例健康体检者为对照组,60例经临床确诊的HLP患者为观察组,采用全自动生化分析仪测定ApoA1、ApoB浓度;采用免疫透射比浊法测定Lipa水平,并进行统计学分析。结果:观察组患者ApoA1含量与对照组比较无明显差异(P>0.05),ApoB含量明显高于对照组,差异有统计学意义(P<0.01),而两种Apo含量之比,即ApoA1/ApoB明显低于对照组,差异有统计学意义(P<0.01);观察组患者血Lipa水平明显高于对照组,差异有统计学意义(P<0.01),与血清ApoA1、ApoB及ApoA1/ApoB均无相关性。结论:HLP患者血清ApoB水平升高和ApoA1/ApoB水平降低,两指标可用于临床诊断HLP;血Lipa水平明显升高,是冠心病(CHD)、动脉粥样硬化(AS)的危险因子。早期干预有可能预防心血管疾病的发生、发展。
Objective: To study the changes of serum apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB) and lipoprotein (Lipa) in patients with hyperlipidemia (HLP) and the correlation between them, and to prevent cardiovascular diseases It is of great significance. Methods: One hundred and twenty healthy individuals were selected as the control group, and 60 patients with clinically diagnosed HLP were selected as observation group. The concentrations of ApoA1 and ApoB were measured by automatic biochemical analyzer. Lipa levels were measured by immunoturbidimetry and analyzed statistically . Results: The content of ApoA1 in the observation group was significantly higher than that in the control group (P> 0.05), and the content of ApoB in the observation group was significantly higher than that in the control group (P <0.01). The ratio of ApoA1 / ApoB was significantly lower than the control group, the difference was statistically significant (P <0.01); the observation group patients with Lipa levels were significantly higher than the control group, the difference was statistically significant (P <0.01), with serum ApoA1, ApoB and ApoA1 / ApoB No correlation. CONCLUSIONS: Serum ApoB levels and ApoA1 / ApoB levels are decreased in patients with HLP. Both markers can be used for the clinical diagnosis of HLP. Blood Lipa levels are significantly elevated and are risk factors for coronary heart disease (CHD) and atherosclerosis (AS). Early intervention may prevent the occurrence and development of cardiovascular diseases.