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目的:观察分析体表胃肠起搏、多潘立酮治疗餐后不适综合征(PDS)患者的近期疗效及生活质量。方法:72例符合PDS罗马Ⅲ标准的患者随机分为3组:多潘立酮组(多潘立酮10 mg,tid)、胃肠起搏组(体表胃肠起搏30 min/d)和联合治疗组(多潘立酮10 mg,tid和体表胃肠起搏30 min/d),疗程均为10 d。治疗前后予以临床症状评分、X线胃排空检测、简明健康状况调查表(SF-36)评估生活质量。健康对照组24例予胃排空检测及SF-36量表评分。结果:①治疗前,PDS患者胃排空及生活质量评分均显著低于健康对照组(P<0.05);②治疗后,PDS 3组的临床症状评分较治疗前显著降低(P<0.05),多潘立酮组与胃肠起搏组临床症状评分无显著差异(P>0.05),均低于联合治疗组(P<0.05);③PDS 3组治疗后,胃排空较治疗前显著改善(P<0.05),3组之间无差异(P>0.05);④治疗后,PDS 3组的生活质量评分均较治疗前显著提高(P<0.05),联合治疗组和胃肠起搏组在精神健康这个维度上较多潘立酮组有显著提高(P<0.05)。结论:体表胃肠起搏是治疗PDS安全有效无创的手段,可缓解症状、改善胃排空、提高生活质量,与多潘立酮的近期疗效相似;与多潘立酮联合使用,更有助于缓解PDS症状。
OBJECTIVE: To observe the short-term effect and quality of life of body surface gastrointestinal pacing and domperidone in patients with postprandial discomfort syndrome (PDS). Methods: Seventy-two patients with PDS Rome III were randomly divided into three groups: domperidone group (domperidone 10 mg, tid), gastrointestinal pacing group (body surface gastrointestinal pacing 30 min / d) and combination therapy group 10 mg, tid, and gastrointestinal pacing for 30 min / d) for 10 days. Before and after treatment, clinical symptoms score, X-ray gastric emptying test and Concise Health Status Questionnaire (SF-36) were used to evaluate the quality of life. 24 cases of healthy control group were given gastric emptying test and SF-36 scale. Results: ① Before treatment, the scores of gastric emptying and quality of life in PDS patients were significantly lower than those in healthy controls (P <0.05); ② After treatment, the score of clinical symptoms in PDS 3 group was significantly lower than that before treatment (P <0.05) There was no significant difference in clinical symptom score between domperidone group and gastrointestinal pacing group (P> 0.05), and both of them were lower than that of combined treatment group (P <0.05) (P> 0.05); ④ After treatment, the quality of life score of PDS 3 group was significantly higher than that before treatment (P <0.05), and the combination therapy group and gastrointestinal pacing group were significantly different in mental health More dominated dimensions were significantly increased (P <0.05). Conclusion: Surface gastrointestinal pacing is a safe and effective noninvasive means to treat PDS. It can relieve symptoms, improve gastric emptying and improve the quality of life, which is similar to that of domperidone in the near future. Combined with domperidone can relieve the symptoms of PDS.